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Astragalus polysaccharide ameliorates adipogenic skewing and dysfunction of bone marrow mesenchymal stromal cells in aplastic anemia via mTOR inhibition

2026-08-20

Abstract excerpt

<title>Abstract</title> <p>BM-MSCs from aplastic anemia (AA) patients show impaired proliferation, elevated apoptosis, and aberrant adipogenic differentiation, thereby generating a microenvironment that inhibits hematopoiesis. Astragalus polysaccharide (APS), a regenerative bioactive component extracted from Astragalus membranaceus, has unclear effects on AA-BM-MSCs. In this study, AA-BM-MSCs were exposed to APS...

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Literature Corpus work
dbe59894-b7c1-588c-ba10-c94bb870d380
DOI
10.21203/rs.3.rs-10457318/v1
Open publication

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Astragalus polysaccharide ameliorates adipogenic skewing and dysfunction of bone marrow mesenchymal stromal cells in aplastic anemia via mTOR inhibitionDOI 10.21203/rs.3.rs-10457318/v1
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