Article

A Pragmatic First-Line Screening Assay for <em>PDGFR </em>Rearrangements: A Real-World Clinical Validation

2026-02-13

Abstract excerpt

Myeloid/lymphoid neoplasms with tyrosine kinase rearrangements (MLN-TK) are rare clonal eosinophilias driven by PDGFRA, PDGFRB and other kinase fusions, highly sensitive to tyrosine kinase inhibitors. Their detection remains challenging, particularly for cryptic PDGFRA rearrangements. We performed a large multicenter real-world validation of the generic quantitative RT-PCR assay (gPDGFR), which detects 3′ PDGFRA/P...

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Literature Corpus work: dbc29935-052b-5e2d-8af7-1f51b88487c8
DOI: 10.20944/preprints202602.1071.v1

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