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Myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions: reevaluation of the defining characteristics in a registry-based cohort

15 Jul 2023

Abstract excerpt

Abstract In a registry-based analysis of 135 patients with “myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions” (MLN-TK; FIP1L1::PDGFRA , n = 78; PDGFRB , diverse fusions, n = 26; FGFR1 , diverse, n = 9; JAK2 , diverse, n = 11; ETV6::ABL1 , n = 11), we sought to evaluate the disease-defining characteristics. In 81/135 (60%) evaluable patients, hypereosinophilia (>1.5 × 10 9 /l) was...

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PMID: 37454239
DOI: 10.1038/s41375-023-01958-1

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