Article

Genomics of PDGFR-rearranged hypereosinophilic syndrome

2022-09-19

Abstract excerpt

A subset of patients with hypereosinophilia have a clonal hematologic neoplasm. These neoplastic hypereosinophilic syndromes (HES) can harbor somatic DNA rearrangements involving a PDGF receptor gene, PDGFRA or PGDFRB , most frequently FIP1L1::PDGFRA . Patients with PDGFR - rearranged HES are overwhelmingly males, and the hypereosinophilia responds robustly to the multi-kinase inhibitor imatinib. Unbiased geno...

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Literature Corpus work: 499f847c-a34a-5369-8d91-1d4644297172
DOI: 10.1101/2022.09.19.508443

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