Article
Genomic and clinical findings in myeloid neoplasms with PDGFRB rearrangement.
Annals of hematology - 1 Feb 2022
Di Giacomo Danika, Quintini Martina, Pierini Valentina, Pellanera Fabrizia, La Starza Roberta, Gorello Paolo, Matteucci Caterina, Crescenzi Barbara, Fiumara Paolo Fabio, Veltroni Marinella, Borlenghi Erika, Albano Francesco, Forghieri Fabio, Maccaferri Monica, Bettelli Francesca, Luppi Mario, Cuneo Antonio, Rossi Giuseppe, Mecucci Cristina
Abstract excerpt
Platelet-derived growth factor receptor B (PDGFRB) gene rearrangements define a unique subgroup of myeloid and lymphoid neoplasms frequently associated with eosinophilia and characterized by high sensitivity to tyrosine kinase inhibition. To date, various PDGFRB/5q32 rearrangements, involving at least 40 fusion partners, have been reported. However, information on genomic and clinical features accompanying...
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