Article

SLC17 transporters mediate renal excretion of Lac-Phe in mice and humans

2024-04-18

Abstract excerpt

N-lactoyl-phenylalanine (Lac-Phe) is a lactate-derived metabolite that suppresses food intake and body weight. Little is known about the mechanisms that mediate Lac-Phe transport across cell membranes. Here we identify SLC17A1 and SLC17A3, two kidney-restricted plasma membrane-localized solute carriers, as physiologic urine Lac-Phe transporters. In cell culture, SLC17A1/3 exhibit high Lac-Phe efflux activity. In h...

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Identifiers and source

Literature Corpus work: db957aee-2c47-5946-b867-5fe793ad0aca
DOI: 10.1101/2024.04.18.589815

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