Article

Direct Transcriptomic Comparison of Xenobiotic Metabolism and Toxicity Pathway Induction of Airway Epithelium Models at an Air Liquid Interface Generated from Induced Pluripotent Stem Cells and Primary Bronchial Epithelial Cells

2021-10-29

Abstract excerpt

<title>Abstract</title> <p>The airway epithelium represents the main barrier between inhaled air and the tissues of the respiratory tract and is therefore an important point of contact with xenobiotic substances into the human body. Several studies have recently shown that <italic>in vitro</italic> models of the airway grown at an air liquid interface (ALI) can be particularly useful to obtain mechanistic informa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: daf30c46-6e3b-558b-848a-0abd533a9200
DOI: 10.21203/rs.3.rs-979260/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Direct Transcriptomic Comparison of Xenobiotic Metabolism and Toxicity Pathway Induction of Airway Epithelium Models at an Air Liquid Interface Generated from Induced Pluripotent Stem Cells and Primary Bronchial Epithelial CellsDOI 10.21203/rs.3.rs-979260/v1Read

Xenobiotic metabolism in differentiated human bronchial epithelial cellsSemantic proximity Read

Targeted omics analyses, and metabolic enzyme activity assays demonstrate maintenance of key mucociliary characteristics in long term cultures of reconstituted human airway epitheliaSemantic proximity Read

Sars-Cov-2 Infects an Upper Airway Model Derived from Induced Pluripotent Stem CellsSemantic proximity Read

Liquid Application Dosing Alters the Physiology of Air-Liquid Interface Primary Bronchial Epithelial Cultures and In Vitro Testing Relevant EndpointsSemantic proximity Read

Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette SmokeSemantic proximity Read

Isolating Bronchial Epithelial Cells from Resected Lung Tissue for Biobanking and Establishing Well-Differentiated Air-Liquid Interface CulturesSemantic proximity Read

Reprogramming of Mouse Fibroblasts to an Intermediate State of Differentiation by Chemical InductionSemantic proximity Read

The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epitheliaSemantic proximity Read

Air-liquid interface culture promotes maturation and allows environmental exposure of pluripotent stem cell–derived alveolar epitheliumSemantic proximity Read

Optimization of Normal Human Bronchial Epithelial (NHBE) Cell 3D Cultures for in vitro Lung Model StudiesSemantic proximity Read

Human lung organoids reveal conserved CYP1A1 and metallothionein activation in response to particulate matter exposureSemantic proximity Read

Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing DNA damage with the CometChip and mutagenesis by Duplex Sequencing.Semantic proximity Read