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Human lung organoids reveal conserved CYP1A1 and metallothionein activation in response to particulate matter exposure

21 Aug 2025

Abstract excerpt

Particulate matter (PM) poses significant adverse impacts on respiratory health, yet most studies investigating PM effects have relied on cancer-derived cell lines or animal models with limited physiological relevance to human lung tissue. To address this limitation, we developed functional lung organoids (hLOs) from human pluripotent stem cells that recapitulate the cellular complexity of human lungs for...

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PMID: 40845642
DOI: 10.1016/j.ecoenv.2025.118909

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