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Article

Nucleolar TFIIE plays a role in ribosomal biogenesis and performance.

Nucleic acids research - 8 Nov 2021

Phan Tamara, Maity Pallab, Ludwig Christina, Streit Lisa, Michaelis Jens, Tsesmelis Miltiadis, Scharffetter-Kochanek Karin, Iben Sebastian

Abstract excerpt

Ribosome biogenesis is a highly energy-demanding process in eukaryotes which requires the concerted action of all three RNA polymerases. In RNA polymerase II transcription, the general transcription factor TFIIH is recruited by TFIIE to the initiation site of protein-coding genes. Distinct mutations in TFIIH and TFIIE give rise to the degenerative disorder trichothiodystrophy (TTD). Here, we uncovered an...

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Source

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Identifiers

PMID: 34581812
DOI: 10.1093/nar/gkab866
PMCID: PMC8565312

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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