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Multi-Omics Modelling of Plasma pTau181, GFAP, and Metabolic Features Enables Risk Stratification in Prodromal Alzheimer’s Disease

2025-11-14

Abstract excerpt

<h4>Background</h4> Mild cognitive impairment (MCI) is a heterogeneous state between normal ageing and dementia, often considered prodromal to Alzheimer’s disease (AD). Progression is variable, and distinguishing stable from progressive MCI remains difficult, particularly in the presence of mixed neuropathology. Blood biomarkers such as phosphorylated tau181 (pTau181), glial fibrillary acidic protein (GFAP), and...

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Literature Corpus work
daa5754c-2e52-555a-a1b2-5fca73c60ab6
DOI
10.1101/2025.11.12.25339932
Open publication

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Multi-Omics Modelling of Plasma pTau181, GFAP, and Metabolic Features Enables Risk Stratification in Prodromal Alzheimer’s DiseaseDOI 10.1101/2025.11.12.25339932
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