Article

Ebola Virus VP35 Hijacks PKA-CREB1 Pathway for Replication and Pathogenesis by AKIP1 Association

2021-01-25

Abstract excerpt

<title>Abstract</title> <p>Ebola virus (EBOV), one of the deadliest viruses, is the cause of fatal Ebola hemorrhagic fever (EHF)<sup>1</sup><sup>,</sup><sup>2</sup>. The underlying mechanism of viral replication and EBOV-related hemorrhage is not fully understood. Here, we show that EBOV VP35, a cofactor of viral RNA-dependent RNA polymerase, binds human A kinase interacting protein (AKIP1), which consequently ac...

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Literature Corpus work: da0ce867-60ed-5882-8254-a0f3b810da6c
DOI: 10.21203/rs.3.rs-138642/v1

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