Article

Trans-activating mutations of the pseudokinase ERBB3

2023-02-15

Abstract excerpt

<title>Abstract</title> <p>Genetic changes in the <italic>ERBB </italic>family of receptor tyrosine kinases serve as oncogenic driver events and predictive biomarkers for ERBB inhibitor drugs. ERBB3 is a pseudokinase member of the family that, although lacking a fully active kinase domain, is well known for its potent signaling activity as a heterodimeric complex with ERBB2. Previous studies have identified few t...

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Literature Corpus work: d9772583-02ca-530f-b718-3a1cd9f9b1fb
DOI: 10.21203/rs.3.rs-2568092/v1

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