Article

CVID-Associated B Cell Activating Factor Receptor Variants Change Receptor Oligomerization, Ligand Binding and Signaling Responses

2021-12-01

Abstract excerpt

<title>Abstract</title> <p><bold>Purpose</bold> B cell activating factor (BAFF) binding to BAFF-receptor(BAFFR) activates essential cellular functions required forthe survival of mature, human B cells. Thus,deletion ofthe BAFFR gene blocks the development of B cells at the transition from immature to mature B cells resulting in B lymphopenia and hypogammaglobulinemia. In addition to complete BAFFR deficiency, sin...

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Literature Corpus work: d96b3c68-50c6-5ad0-a8e3-e2b1d1b18945
DOI: 10.21203/rs.3.rs-1068596/v1

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