Article
B-cell defects in common variable immunodeficiency: BCR signaling, protein clustering and hardwired gene mutations.
Critical reviews in immunology - 1 Jan 2011
van de Ven Annick A J M, Compeer Ewoud B, van Montfrans Joris M, Boes Marianne
Abstract excerpt
Common variable immunodeficiency (CVID) is the most frequently diagnosed symptomatic primary immunodeficiency. CVID develops as a consequence of absence or malfunction of proteins involved with immunoglobulin production by plasma and memory B-cells. The last decade has brought us clarification of several genetic predispositions to the development of CVID. Despite considerable effort, however, for eighty-five...
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