Article

Small molecules inhibit SARS-COV-2 induced aberrant inflammation and viral replication in mice by targeting S100A8/A9-TLR4 axis

2020-09-09

Abstract excerpt

<h4>Summary</h4> The SARS-CoV-2 pandemic poses an unprecedented public health crisis. Accumulating evidences suggest that SARS-CoV-2 infection causes dysregulation of immune system. However, the unique signature of early immune responses remains elusive. We characterized the transcriptome of rhesus macaques and mice infected with SARS-CoV-2. Alarmin S100A8 was robustly induced by SARS-CoV-2 in animal models as we...

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Literature Corpus work: 7df11e96-d8ff-5d1c-b6ea-fbf6e5aaa9c6
DOI: 10.1101/2020.09.09.288704

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Small molecules inhibit SARS-COV-2 induced aberrant inflammation and viral replication in mice by targeting S100A8/A9-TLR4 axisDOI 10.1101/2020.09.09.288704Read

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