Article

Evolutionary arms race between SARS-CoV-2 and interferon signaling via dynamic interaction with autophagy

2023-11-16

Abstract excerpt

SARS-CoV-2 emerged, and is evolving to efficiently infect humans worldwide. SARS-CoV-2 evades early innate recognition, interferon signaling activated only in bystander cells. This balance of innate activation and viral evasion has important consequences, but the pathways involved are incompletely understood. Here we find that autophagy genes regulate innate immune signaling, impacting the basal set point of inter...

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Literature Corpus work: d9167800-4b4e-5bf1-85b8-3bc49a2c2799
DOI: 10.1101/2023.11.13.566859

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