Article

Whole Exome Analysis to Select Targeted Therapies for Patients with Metastatic Breast or Advanced Gynecological Cancer -A Feasibility Study-

2022-08-26

Abstract excerpt

In this feasibility study we applied next generation sequencing (NGS) based whole exome sequencing (WES) of tumor tissue and peripheral blood of patients with metastatic breast (MBC, n = 44) or advanced gynecological cancer (AGC, n = 8). The purpose was to select targeted therapies according to “ESMO Scale for Clinical Actionability of molecular Targets (ESCAT)”. Data interpretation was further supported by a brow...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d9044c12-003a-53f9-84fb-774af1655634
DOI: 10.21203/rs.3.rs-1893274/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Whole Exome Analysis to Select Targeted Therapies for Patients with Metastatic Breast or Advanced Gynecological Cancer -A Feasibility Study-DOI 10.21203/rs.3.rs-1893274/v1Read

Comprehensive Genomic Profiling of Taiwanese Breast Cancer Using a Novel Targeted Sequencing PanelSemantic proximity Read

Development and validation of a targeted next generation DNA sequencing panel outperforming whole exome sequencing for the identification of clinically relevant genetic variantsSemantic proximity Read

Comprehensive molecular profiling of Taiwanese breast cancers revealed potential therapeutic targets: prevalence of actionable mutations among 380 targeted sequencing analysesSemantic proximity Read

Clinical benefit of additional whole-exome sequencing over panel sequencing in an all-comer real-world molecular tumor boardSemantic proximity Read

Clinical Application of Next-Generation Sequencing in Patients With Breast Cancer: Real-World DataSemantic proximity Read

Impact of clinical targeted sequencing on endocrine responsiveness in estrogen receptor-positive, HER2-negative metastatic breast cancer.Semantic proximity Read

Mutational Profile of Metastatic Breast Cancers: A Retrospective Analysis.Semantic proximity Read

Implementation and use of whole exome sequencing for metastatic solid cancer.Semantic proximity Read

Clinical implications of prospective genomic profiling of metastatic breast cancer patients.Semantic proximity Read

Genomic alterations in breast cancer: level of evidence for actionability according to ESMO Scale for Clinical Actionability of molecular Targets (ESCAT)Semantic proximity Read

Multi-Gene Testing Overview with a Clinical Perspective in Metastatic Triple-Negative Breast Cancer.Semantic proximity Read

SeqOIA platform, an integrative and interactive approach to optimize personalized cancer treatmentSemantic proximity Read