Implementation and use of whole exome sequencing for metastatic solid cancer.

doi:10.1016/j.ebiom.2019.102624

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Article

Implementation and use of whole exome sequencing for metastatic solid cancer.

EBioMedicine - 1 Jan 2020

Réda Manon, Richard Corentin, Bertaut Aurelie, Niogret Julie, Collot Thomas, Fumet Jean David, Blanc Julie, Truntzer Caroline, Desmoulins Isabelle, Ladoire Sylvain, Hennequin Audrey, Favier Laure, Bengrine Leila, Vincent Julie, Hervieu Alice, Dusserre Jean-Florian Guion, Lepage Come, Foucher Pascal, Borg Christophe, Albuisson Juliette, Arnould Laurent, Nambot Sophie, Faivre Laurence, Boidot Romain, Ghiringhelli Francois

Abstract excerpt

BACKGROUND: Genomically-guided clinical trials are performed across different tumor types sharing genetic mutations, but trial organization remains complex. Here we address the feasibility and utility of routine somatic and constitutional exome analysis in metastatic cancer patients. METHODS: Exoma trial (NCT02840604) is a multicenter, prospective clinical trial. Eligible patients presented a metastatic cancer...

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Identifiers

PMID: 31923800
DOI: 10.1016/j.ebiom.2019.102624
PMCID: PMC7000332

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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