Article

Extract of the mushroom Mycoleptodonoides aitchisonii induces a series of anti-oxidative and phase II detoxifying enzymes through activation of the transcription factor Nrf2

2011-11-01

Abstract excerpt

Activation of the transcriptional factor Nrf2 is a powerful strategy for protecting oxidative stress-related disease. To find novel compounds from mushrooms, the NAD(P)H:quinone oxidoreductase 1 (NQO1)-inducing activity of 43 ethyl-acetate extracts of mushrooms were examined using Hepa1c1c7 cells. In this screening, an extract of Mycoleptodonoides aitchisonii significantly induced NQO1. This extract also increased...

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Literature Corpus work: d8e145ef-08ff-55e4-b772-fd98d38d6b29
DOI: 10.1016/j.foodchem.2011.04.031

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