Article

Evolutionary Constraints on Positional Sequence, Collective Properties and Sequence Style of Tropoelastin Dictated by Fundamental Requirements for Formation and Function of the Extracellular Elastic Matrix

2024-12-04

Abstract excerpt

Elastin is an unusual extracellular matrix protein responsible for the properties of extension and energy-efficient elastic recoil of large blood vessels, heart valves, lung parenchyma and many other vertebrate tissues requiring such resilience. Polymeric elastin is assembled from monomeric tropoelastin by a process involving liquid-liquid phase separation, followed by maturation into an extended elastic matrix, c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d8a1d3ed-7a86-59b4-8338-9abac0f8c9f4
DOI: 10.1101/2024.12.03.626628

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Evolutionary Constraints on Positional Sequence, Collective Properties and Sequence Style of Tropoelastin Dictated by Fundamental Requirements for Formation and Function of the Extracellular Elastic MatrixDOI 10.1101/2024.12.03.626628Read

Single nucleotide polymorphisms and domain/splice variants modulate assembly and elastomeric properties of human elastin. Implications for tissue specificity and durability of elastic tissue.Semantic proximity Read

Polymorphisms in the human tropoelastin gene modify in vitro self-assembly and mechanical properties of elastin-like polypeptides.Semantic proximity Read

A negatively charged residue stabilizes the tropoelastin N-terminal region for elastic fiber assembly.Semantic proximity Read

Dissection of human tropoelastin: Supramolecular organization of polypeptide sequences coded by particular exonsSemantic proximity Read

A synthetic elastic protein as molecular prosthetic candidate to strengthen vascular wall elasticitySemantic proximity Read

Elastin-driven genetic diseases.Semantic proximity Read

Alternative splicing and tissue-specific elastin misassembly act as biological modifiers of human elastin gene frameshift mutations associated with dominant cutis laxa.Semantic proximity Read

The collagen superfamily--diverse structures and assemblies.Semantic proximity Read

The evolutionary background and functional consequences of the rs2071307 polymorphism in human tropoelastin.Semantic proximity Read

Molecular model of human tropoelastin and implications of associated mutations.Semantic proximity Read

The development of the amnion in mice and other amniotesSemantic proximity Read

Multi-species sequence comparison reveals dynamic evolution of the elastin gene that has involved purifying selection and lineage-specific insertions/deletions.Semantic proximity Read