Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms in the human tropoelastin gene modify in vitro self-assembly and mechanical properties of elastin-like polypeptides.

PloS one - 1 Jan 2012

He David, Miao Ming, Sitarz Eva E, Muiznieks Lisa D, Reichheld Sean, Stahl Richard J, Keeley Fred W, Parkinson John

Abstract excerpt

Elastin is a major structural component of elastic fibres that provide properties of stretch and recoil to tissues such as arteries, lung and skin. Remarkably, after initial deposition of elastin there is normally no subsequent turnover of this protein over the course of a lifetime. Consequently, elastic fibres must be extremely durable, able to withstand, for example in the human thoracic aorta, billions of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomyopathy and Myosin Studies
Share to Connective tissue disorders research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Elastin

Share to ELN gene

Share to Mutation

Share to Peptides

Share to Polymorphism, Single Nucleotide

Share to Williams Syndrome Research

Source

Open in PubMed Open full text

Identifiers

PMID: 23049958
DOI: 10.1371/journal.pone.0046130
PMCID: PMC3458006

Genes

ELN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms in the human tropoelastin gene modify in vitro self-assembly and mechanical properties of elastin-like polypeptides.PMID 23049958Read ↗

Single nucleotide polymorphisms and domain/splice variants modulate assembly and elastomeric properties of human elastin. Implications for tissue specificity and durability of elastic tissue.Semantic proximity Read ↗

Elastin-driven genetic diseases.Semantic proximity Read ↗

Alternative splicing and tissue-specific elastin misassembly act as biological modifiers of human elastin gene frameshift mutations associated with dominant cutis laxa.Semantic proximity Read ↗

An elastin gene mutation producing abnormal tropoelastin and abnormal elastic fibres in a patient with autosomal dominant cutis laxaSemantic proximity Read ↗

Elastin, arterial mechanics, and cardiovascular diseaseSemantic proximity Read ↗

Evolutionary Constraints on Positional Sequence, Collective Properties and Sequence Style of Tropoelastin Dictated by Fundamental Requirements for Formation and Function of the Extracellular Elastic MatrixSemantic proximity Read ↗

A synthetic elastic protein as molecular prosthetic candidate to strengthen vascular wall elasticitySemantic proximity Read ↗

Domains in tropoelastin that mediate elastin deposition in vitro and in vivo.Semantic proximity Read ↗

Collagens and elastin genetic variations and their potential role in aging-related diseases and longevity in humans.Semantic proximity Read ↗

Unique molecular networks: Formation and role of elastin cross‐linksSemantic proximity Read ↗

Elastic tissue disruption is a major pathogenic factor to human vascular disease.Semantic proximity Read ↗

Phenotypic findings associated with variation in elastin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.