Back to search

Article

Functional characterization of BRCA2 variants of uncertain significance identified in Korean breast cancer patients

2026-02-13

Abstract excerpt

<title>Abstract</title> <p> Background Variants of uncertain significance (VUS) in <italic>BRCA2</italic> remain a major challenge in the clinical management of breast cancer, particularly in Asian populations where population-specific reference data are limited. Functional assays may provide complementary biological evidence to support interpretation of these variants. Patients and methods: Three <italic>B...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d868945d-e47c-596a-b99f-6e137d8df1e2
DOI
10.21203/rs.3.rs-8617436/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Functional characterization of BRCA2 variants of uncertain significance identified in Korean breast cancer patientsDOI 10.21203/rs.3.rs-8617436/v1
BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer.Semantic proximity
Analysis of BRCA1/2 variants of unknown significance in patients with breast cancer from a prospective KOHBRA studySemantic proximity
Clinically Significant Unclassified Variants in BRCA1 and BRCA2 genes among Korean Breast Cancer Patients.Semantic proximity
Prevalence of BRCA1, BRCA2, and PALB2 genomic alterations among 924 Taiwanese breast cancer assays with tumor-only targeted sequencing: extended data analysis from the VGH-TAYLOR studySemantic proximity
Imprecise Medicine: BRCA2 Variants of Uncertain Significance (VUS), the Challenges and Benefits to Integrate a Functional Assay Workflow with Clinical Decision Rules.Semantic proximity
Analysis of BRCA1/2 variants of unknown significance in the prospective Korean Hereditary Breast Cancer study.Semantic proximity
High-Throughput Functional Evaluation of <i>BRCA2</i> Variants of Unknown SignificanceSemantic proximity
Functional evaluation of BRCA1/2 variants of unknown significance with homologous recombination assay and integrative in silico prediction model.Semantic proximity
BRCA1 and BRCA2 germline mutation analysis from a cohort of 1,267 high-risk breast cancer patients in BrazilSemantic proximity
A novel loss-of-function heterozygous BRCA2 c.8946_8947delAG mutation found in a Chinese woman with family history of breast cancer.Semantic proximity
Characterization of BRCA1 and BRCA2 variants in multi-ethnic Asian cohort from a Malaysian case-control study.Semantic proximity
Prevalence of BRCA1, BRCA2, and PALB2 genomic alterations among 924 Taiwanese breast cancer assays with tumor-only targeted sequencing: extended data analysis from the VGH-TAYLOR study.Semantic proximity
Select a neighboring publication to make it the new centre.