Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Analysis of BRCA1/2 variants of unknown significance in the prospective Korean Hereditary Breast Cancer study.

Scientific reports - 19 Apr 2021

Kim Joo Heung, Park Sunggyun, Park Hyung Seok, Park Ji Soo, Lee Seung-Tae, Kim Sung-Won, Lee Jong Won, Lee Min Hyuk, Park Sue K, Noh Woo-Chul, Choi Doo Ho, Han Wonshik, Jung Sung Hoo

Abstract excerpt

Genetic testing for BRCA1 and BRCA2 is crucial in diagnosing hereditary breast and ovarian cancer syndromes and has increased with the development of multigene panel tests. However, results classified as variants of uncertain significance (VUS) present challenges to clinicians in attempting to choose an appropriate management plans. We reviewed a total of 676 breast cancer patients included in the Korean...

Topics

Adult
BRCA1 Protein
BRCA2 Protein
Breast Neoplasms
Female
Genetic Testing
Hereditary Breast and Ovarian Cancer Syndrome
Humans
Mutation
Prospective Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Republic of Korea

Source

Open in PubMed Open full text

Identifiers

PMID: 33875706
DOI: 10.1038/s41598-021-87792-w
PMCID: PMC8055990

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of BRCA1/2 variants of unknown significance in the prospective Korean Hereditary Breast Cancer study.PMID 33875706Read ↗

Analysis of BRCA1/2 variants of unknown significance in patients with breast cancer from a prospective KOHBRA studySemantic proximity Read ↗

Clinically Significant Unclassified Variants in BRCA1 and BRCA2 genes among Korean Breast Cancer Patients.Semantic proximity Read ↗

Unclassified Variants of BRCA1 and BRCA2 in Korean Patients With Ovarian Cancer.Semantic proximity Read ↗

Reclassification of BRCA1 and BRCA2 variants found in ovarian epithelial, fallopian tube, and primary peritoneal cancers.Semantic proximity Read ↗

How does re-classification of variants of unknown significance (VUS) impact the management of patients at risk for hereditary breast cancer?Semantic proximity Read ↗

BRCA1/2 variants of unknown significance in hereditary breast and ovarian cancer (HBOC) syndrome: Looking for the hidden meaning.Semantic proximity Read ↗

A Study on the Retrospective Reinterpretation of BRCA1 and BRCA2 Variants.Semantic proximity Read ↗

Comparative analysis of BRCA1 and BRCA2 variants of uncertain significance in patients with breast cancer: a multifactorial probability-based model versus ACMG standards and guidelines for interpreting sequence variants.Semantic proximity Read ↗

The prevalence and spectrum of BRCA1 and BRCA2 mutations in Korean population: recent update of the Korean Hereditary Breast Cancer (KOHBRA) study.Semantic proximity Read ↗

Changes in classification of genetic variants in BRCA1 and BRCA2.Semantic proximity Read ↗

Clinicopathological characteristics and BRCA1/BRCA2 pathogenic variants of patients with breast cancer.Semantic proximity Read ↗

Suggestion of BRCA1 c.5339T>C (p.L1780P) variant confer from 'unknown significance' to 'Likely pathogenic' based on clinical evidence in Korea.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.