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Shifting of blaKPC-2 to blaKPC-90 in a sequence type 11 Klebsiella pneumoniae strain before the use of ceftazidime-avibactam.

BMC genomics - 19 Feb 2026

Hu Dakang, Zhao Yuanxun, Mi Shuli, Wang Shijie, Zhang Jin, Luo Xinhua, Li Dan, Chen Jin, Hong Guolin

Abstract excerpt

BACKGROUND: Klebsiella pneumoniae continues to be a problem worldwide. This study aimed to elucidate the evolution of a K. pneumoniae strain from harbouring blaKPC−2 to blaKPC−90. METHODS: Three K. pneumoniae strains (Kpn_XM11, Kpn_XM12, and Kpn_XM13) belonging to the same clone were isolated from a patient, followed by identification, antimicrobial susceptibility test, whole genome sequencing, and gene...

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Identifiers

PMID: 41714956
DOI: 10.1186/s12864-026-12638-6
PMCID: PMC13023152

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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