Article

PepCL: A replay-based continual learning framework for updating peptide-MHC models

2026-07-21

Abstract excerpt

Understanding peptide-major histocompatibility complex (MHC) class I binding is critical for effective vaccine and immunotherapy design but is a combinatorially complex challenge for which prediction models have become essential. MHC ligands are typically identified at scale via untargeted mass spectrometry (MS), and this has built a strong base for peptide-MHC model training. However, MS incompletely captures the...

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Literature Corpus work: d8443c81-697e-591b-85b2-e354bcdf259d
DOI: 10.64898/2026.07.20.733558

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