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Intracellular S100A9 Promotes Myeloid-Derived Suppressor Cells during Late Sepsis

17 Nov 2017

Abstract excerpt

Myeloid precursor cell reprogramming into a myeloid-derived suppressor cell (MDSC) contributes to high mortality rates in mouse and human sepsis. S100A9 mRNA and intracellular protein levels increase during early sepsis and remain elevated in Gr1+CD11b+ MDSCs after pro-inflammatory sepsis transitions to the later chronic anti-inflammatory and immunosuppressive phenotype. The purpose of this study was to determine...

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PMID: 29204146
DOI: 10.3389/fimmu.2017.01565

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