Article

The efficient induction of human retinal ganglion-like cells provides a platform for studying optic neuropathies

2023-07-01

Abstract excerpt

<h4>ABSTRACT</h4> Retinal ganglion cells (RGCs) are essential for vision perception. In glaucoma and other optic neuropathies, RGCs and their optic axons undergo degenerative change and cell death; this can result in irreversible vision loss. Here we developed a rapid protocol for directly inducing RGC differentiation from human induced pluripotent stem cells (iPSCs) by the overexpression of ATOH7 , BRN3B and...

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Literature Corpus work: d7ff3a05-9f2b-5eaf-8657-e18f8431fd30
DOI: 10.1101/2023.07.01.547305

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