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Article

Artificial intelligence for sleep instability and motor phenotyping: clinical translation beyond sleep staging.

Sleep - 14 Aug 2026

Mogavero Maria Paola, Bruni Oliviero, Lanza Giuseppe, Faraguna Ugo, Silvani Alessandro, Ferri Raffaele

Abstract excerpt

Sleep medicine has rapidly adopted artificial intelligence (AI), but most applications still prioritize automated sleep staging or single summary indices, limiting clinical translation when symptoms arise from within-stage dynamics. This review proposes a physiology-grounded framework in which AI targets sleep microstructure and nocturnal motor activity as temporally structured expressions of sleep-wake control....

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PMID: 42213077
DOI: 10.1093/sleep/zsag149

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