Article

Anlotinib Exerts Potent Antileukemic Activities in B-Cell Acute Lymphoblastic Leukemia Via Attenuation of PI3K/AKT/mTOR Signaling Cascade

2021-07-30

Abstract excerpt

<h4>Background: </h4> Adult patients with B-cell acute lymphoblastic leukemia (B-ALL) have unfavorable prognosis. Recurrent disease is the major challenge for treatment success and has limited effective therapeutic strategies, suggesting that alternative therapeutics are unmet medical needs. Anlotinib, a novel multi-target inhibitor, is capable of blunting the proangiogenic activity of VEGFR, PDGFR and FGFR, and h...

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Literature Corpus work: d7b6ccc1-1042-594f-97be-fc418ab9c63b
DOI: 10.21203/rs.3.rs-728100/v1

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