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Anlotinib Induced Venetoclax-resistant Acute Myeloid Leukemia Stem Cells Apoptosis through Downregulating Mcl-1-mediated Anti-apoptoeic Pathway

2025-12-01

Abstract excerpt

<title>Abstract</title> <p>Acute myeloid leukemia (AML) is characterized by uncontrolled proliferation of leukemia stem cells (LSCs), which drive relapse and therapeutic resistance through mechanisms such as Mcl-1–mediated apoptosis evasion. Venetoclax, a selective Bcl-2 inhibitor, induces apoptosis in LSCs but is limited by acquired resistance. Anlotinib, a multi-target tyrosine kinase inhibitor, has demonstrate...

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Literature Corpus work
32cd45af-07b6-5af8-82e8-8a57518ac47f
DOI
10.21203/rs.3.rs-7977627/v1
Open publication

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Anlotinib Induced Venetoclax-resistant Acute Myeloid Leukemia Stem Cells Apoptosis through Downregulating Mcl-1-mediated Anti-apoptoeic PathwayDOI 10.21203/rs.3.rs-7977627/v1
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