Article

DoliClock: A Lipid-Based Aging Clock Reveals Accelerated Aging in Neurological Disorders

2024-02-02

Abstract excerpt

Aging is a multifaceted process influenced by intrinsic and extrinsic factors, with lipid alterations playing a critical role in brain aging and neurological disorders. This study introduces DoliClock, a lipid-based biological aging clock designed to predict the age of the prefrontal cortex using post-mortem lipidomic data. Significant age acceleration was observed in samples with autism, schizophrenia, and Down s...

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Literature Corpus work: d75163c8-830d-5d7c-b06a-9e81219a91da
DOI: 10.1101/2024.02.01.578331

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