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A novel transcript of LncRNA ELDR promotes chondrocyte senescence and osteoarthritis progression by tuning chromosomal dynamics

2022-06-10

Abstract excerpt

Epigenetic reprogramming plays a critical role in chondrocyte senescence during osteoarthritis (OA) pathology, but the underlying molecular mechanisms remain to be elucidated. Here using large-scale patient data sets and genetically engineered (Col2a1-CreERT2;Eldrflox/flox and Col2a1-CreERT2;ROSA26-LSL-Eldr+/+ KI) mouse models, we show that a novel transcript of long noncoding RNA ELDR is essential for the develop...

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Literature Corpus work
d71501d8-0f33-530e-ae5e-376fc6a8a674
DOI
10.21203/rs.3.rs-1645805/v1
Open publication

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A novel transcript of LncRNA ELDR promotes chondrocyte senescence and osteoarthritis progression by tuning chromosomal dynamicsDOI 10.21203/rs.3.rs-1645805/v1
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