Article
Precise and efficient DNA base editing restores normal hearing in adult DFNB9 mouse model.
Med (New York, N.Y.) - 10 Apr 2026
Zhang Ziyu, Wang Man, Tan Fangzhi, Zhang Liyan, Wang Xiaohan, Chen Xiangyan, Han Jia, Li Nianci, Sun Qiuhan, Lu Yicheng, Cui Zhiping, He Zuhong, Qi Jieyu, Chai Renjie
Abstract excerpt
BACKGROUND: Mutations in the OTOF gene, which cause autosomal recessive non-syndromic hearing loss, DFNB9, are a leading cause of auditory neuropathy. Gene augmentation and RNA and DNA editing have been used to restore the auditory function of mouse models, and gene augmentation has even been used in patients with DFNB9. However, the therapeutic time window for DFNB9 treatment is largely unknown. METHODS: We...
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