Article

Synthetic Lethality-Based Prediction of Anti-SARS-CoV-2 Targets

2021-10-20

Abstract excerpt

Novel strategies are needed to identify drug targets and treatments for the COVID-19 pandemic. The altered gene expression of virus-infected host cells provides an opportunity to specifically inhibit viral propagation via targeting the synthetic lethal (SL) partners of such altered host genes. Pursuing this antiviral strategy, here we comprehensively analyzed multiple <i>in vitro</i> and <i>in vivo<i> bulk and sin...

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Literature Corpus work: d6661a91-788b-5e16-b52c-a722e0385eb8
DOI: 10.2139/ssrn.3946570

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