Article

Synthetic lethality-based prediction of anti-SARS-CoV-2 targets

2021-09-15

Abstract excerpt

Novel strategies are needed to identify drug targets and treatments for the COVID-19 pandemic. The altered gene expression of virus-infected host cells provides an opportunity to specifically inhibit viral propagation via targeting the synthetic lethal (SL) partners of such altered host genes. Pursuing this antiviral strategy, here we comprehensively analyzed multiple in vitro and in vivo bulk and single-cell RN...

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Literature Corpus work: ee7eff42-cecf-58aa-a57d-df8f2f346a08
DOI: 10.1101/2021.09.14.460408

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