Article

Extracellular vesicles induce aggressive lung cancer via non-canonical integrin-EGFR-KRAS signaling

2022-08-16

Abstract excerpt

Small cell lung cancer (SCLC) is an extremely aggressive lung cancer type with a patient median survival of 6-12 months. Epidermal growth factor (EGF) signaling plays an important role in triggering SCLC. In addition, growth factor-dependent signals and alpha-, beta-integrin (ITGA, ITGB) heterodimer receptors functionally cooperate and integrate their signaling pathways. However, the precise role of integrins in E...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d652d7b9-e7fc-543e-a53f-9e3f018ed498
DOI: 10.1101/2022.08.16.504078

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Extracellular vesicles induce aggressive lung cancer via non-canonical integrin-EGFR-KRAS signalingDOI 10.1101/2022.08.16.504078Read

Non-canonical integrin signaling activates EGFR and RAS-MAPK-ERK signaling in small cell lung cancer.Semantic proximity Read

Dynamic phenotypic reprogramming and chemoresistance induced by lung fibroblasts in small cell lung cancer.Semantic proximity Read

Use of four genes in exosomes as biomarkers for the identification of lung adenocarcinoma and lung squamous cell carcinomaSemantic proximity Read

Extracellular Vesicle-Associated miRNAs as a Biomarker for Lung Cancer in Liquid BiopsySemantic proximity Read

Lung adenocarcinoma-specific three-integrin signature contributes to poor outcomes by metastasis and immune escape pathwaysSemantic proximity Read

What is the impact of ITGβ8 on NSCLC: A systematic studySemantic proximity Read

OR7E47P regulates TGF-β secretion of fibroblast via ROBO2 pathway to modulate the TME in NSCLCSemantic proximity Read

Single-cell transcriptome atlas of lung adenocarcinoma featured with ground glass nodulesSemantic proximity Read

Quantitative Secretomic Analysis Identifies Extracellular Protein Factors That Modulate the Metastatic Phenotype of Non-Small Cell Lung Cancer.Semantic proximity Read

Extracellular vesicles from subjects with COPD modulate cancer initiating cells phenotype through HIF-1α shuttling.Semantic proximity Read

RAB27B Drives a Cancer Stem Cell Phenotype in NSCLC Cells Through Enhanced Extracellular Vesicle Secretion.Semantic proximity Read

Expression and prognostic analyses of ITGA11 , ITGB4 and ITGB8 in human non-small cell lung cancerSemantic proximity Read