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Article

RAB27B Drives a Cancer Stem Cell Phenotype in NSCLC Cells Through Enhanced Extracellular Vesicle Secretion.

Cancer research communications - 1 Apr 2023

Meneses Kayleah M, Pandya Prita, Lindemann Jennifer A, Al-Qasrawi Dania S, Argo Ryan A, Weems Celeste M, Beetler Danielle J, Vijay Geraldine V, Yan Irene K, Wolfram Joy, Patel Tushar, Justilien Verline

Abstract excerpt

Cancer stem cells (CSC) within non-small cell lung carcinoma (NSCLC) tumors drive NSCLC progression, metastasis, relapse, and intrinsic chemoresistance. Understanding the mechanisms that support the malignant phenotypes of NSCLC CSCs may provide insights for improved NSCLC therapeutic interventions. Here, we report that expression of RAB27B, a small GTPase, is significantly upregulated in NSCLC CSCs when compared...

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Share to Carcinoma, Non-Small-Cell Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Vesicles

Share to Extracellular vesicles in disease

Share to Lung Neoplasms

Share to Neoplasm Recurrence, Local

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Source

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Identifiers

PMID: 37077938
DOI: 10.1158/2767-9764.CRC-22-0425
PMCID: PMC10109210

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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