Article

Cytotoxic and regulatory CD8 T cells dynamics underlies ICI-myotoxicity outcome

2026-03-10

Abstract excerpt

Immune checkpoint inhibitor–induced myotoxicity (ICI-M) comprises myocarditis, myositis, and myasthenia gravis–like syndrome, demanding rapid recognition and therapy. Using immunophenotyping and transcriptomics analysis from blood and muscle, we identified distinct CD38 hi and KIR + CD8 T cells in ICI-M. Abatacept rescued patients and altered the composition and clonality of these cells. Dynamics of CD38 hi and...

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Literature Corpus work: d64cc945-e31f-583a-adf9-c9cb22e79e08
DOI: 10.64898/2026.03.03.26347221

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