Article

YAP–TEAD-driven CPA4 promotes NF2-deficient meningioma growth

2026-08-07

Abstract excerpt

<h4>ABSTRACT</h4> Neurofibromin 2 (NF2) deficiency is a driver of meningioma and other cancers, yet transcriptional effectors that sustain NF2-deficient tumors remain poorly defined. We identify carboxypeptidase A4 (CPA4) as an effector of YAP–TEAD signaling in NF2-deficient meningioma. Transcriptomic profiling identified CPA4 as a consistently upregulated effector. Across patient cohorts and specimens, CPA4 expr...

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Identifiers and source

Literature Corpus work: d648dde6-86e0-527f-8203-bfcefc7ba738
DOI: 10.64898/2026.08.05.743013

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