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Computational Drug Repurposing and Molecular Interaction Analysis of Olaparib Targeting Acetylcholinesterase: A Molecular Docking, ADME, Toxicity, and Molecular Dynamics Study

2026-05-20

Abstract excerpt

<title>Abstract</title> <p>Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by cholinergic deficits arising from excessive acetylcholinesterase (AChE)-mediated hydrolysis of acetylcholine, and represents the leading cause of dementia worldwide. Olaparib, an FDA-approved poly(ADP-ribose) polymerase (PARP) inhibitor, has demonstrated neuroprotective properties in precli...

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Literature Corpus work
d62f7bce-c59a-5be0-b74a-ba8a66090843
DOI
10.21203/rs.3.rs-9560433/v1
Open publication

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Computational Drug Repurposing and Molecular Interaction Analysis of Olaparib Targeting Acetylcholinesterase: A Molecular Docking, ADME, Toxicity, and Molecular Dynamics StudyDOI 10.21203/rs.3.rs-9560433/v1
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