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Article

A molecular and cellular hypothesis for aminoglycoside-induced deafness.

Hearing research - 1 Jul 1994

Cortopassi G, Hutchin T

Abstract excerpt

The ototoxic effects of aminoglycoside antibiotics are well known. However, a molecular and cellular mechanism for the death of cochlear hair cells has remained difficult to prove. Human genetic studies have shown that a rare trait for hypersensitivity to aminoglycosides is conferred by mitochondrial genetic variation. Recently, a gene involved has been identified as the mitochondrial small ribosomal RNA gene,...

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Identifiers

PMID: 7961174
DOI: 10.1016/0378-5955(94)90040-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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