Article
A molecular and cellular hypothesis for aminoglycoside-induced deafness.
Hearing research - 1 Jul 1994
Cortopassi G, Hutchin T
Abstract excerpt
The ototoxic effects of aminoglycoside antibiotics are well known. However, a molecular and cellular mechanism for the death of cochlear hair cells has remained difficult to prove. Human genetic studies have shown that a rare trait for hypersensitivity to aminoglycosides is conferred by mitochond...
Topics
- Aminoglycosides
- Asian People
- Base Sequence
- Deafness
- Drug Hypersensitivity
- Gene Frequency
- Hair Cells, Auditory
- Humans
- Models, Biological
- Molecular Sequence Data
- Mutation
- Pedigree
- RNA, Ribosomal
- RNA, Ribosomal, 16S