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Targeted Sequencing Workflows for Comprehensive Drug Resistance Profiling of <i>Mycobacterium tuberculosis</i> cultures using Illumina MiSeq and Nanopore MinION: Comparison of analytical and diagnostic performance, turnaround time and cost

2019-09-08

Abstract excerpt

The emergence of Mycobacterium tuberculosis strains with complex drug resistance profiles necessitates a rapid and extensive drug susceptibility test for comprehensive guidance of patient treatment. Here, we developed two targeted-sequencing workflows based on Illumina MiSeq and Nanopore MinION for the prediction of drug resistance in M. tuberculosis towards 12 anti-tuberculous agents. A total of 163 M. tuberc...

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Literature Corpus work
d5cb1f03-33c6-5583-a58a-32dd1b5ee4d0
DOI
10.1101/760462
Open publication

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