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The integration of genetically-regulated transcriptomics and electronic health records highlights a pattern of medical outcomes related to increased hepatic<i>Transthyretin</i>expression

2021-07-18

Abstract excerpt

<h4>Background</h4> Transthyretin (TTR) is a multi-function protein involved in the systemic transport of retinol and thyroxine. It also participates in the neuronal response to stress and proteolysis of few specific substrates. TTR is also the precursor of the fibrils that compromise organ function in the familial and sporadic systemic amyloidoses (ATTR). RNA-interference and anti-sense therapeutics targeting TTR...

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Literature Corpus work
d5adf0da-2e6e-5fe4-8cf8-20dd4e416f60
DOI
10.1101/2021.07.14.21260525
Open publication

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