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Article

Population diversity of the genetically determined TTR expression in human tissues and its implications in TTR amyloidosis.

BMC genomics - 23 Mar 2017

Iorio Andrea, De Angelis Flavio, Di Girolamo Marco, Luigetti Marco, Pradotto Luca G, Mazzeo Anna, Frusconi Sabrina, My Filomena, Manfellotto Dario, Fuciarelli Maria, Polimanti Renato

Abstract excerpt

BACKGROUND: Transthyretin (TTR) amyloidosis is a hereditary disease with a complex genotype-phenotype correlation. We conducted a literature survey to define the clinical landscape of TTR amyloidosis across populations worldwide. Then, we investigated whether the genetically determined TTR expression differs among human populations, contributing to the differences observed in patients. Polygenic scores for...

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Source

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Identifiers

PMID: 28335735
DOI: 10.1186/s12864-017-3646-1
PMCID: PMC5364715

Genes

TTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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