Article
In silico analysis of TTR gene (coding and non-coding regions, and interactive network) and its implications in transthyretin-related amyloidosis.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis - 1 Sept 2014
Polimanti Renato, Di Girolamo Marco, Manfellotto Dario, Fuciarelli Maria
Abstract excerpt
INTRODUCTION: Transthyretin (TTR)-related amyloidosis is a life-threatening disease. Currently, several questions about the pathogenic mechanisms of TTR-related amyloidosis remain unanswered. METHODS: We have investigated various TTR-related issues using different in silico approaches. RESULTS: Using an amino acid similarity-based analysis, we have indicated the most relevant TTR secondary structures in...
Topics
- Algorithms
- Amyloid Neuropathies, Familial
- Computer Simulation
- CpG Islands
- DNA Methylation
- Databases, Genetic
- Epigenesis, Genetic
- Haplotypes
- Humans
- Models, Molecular
- Mutation
- Open Reading Frames