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Phenome-wide association study of <i>TTR</i> and <i>RBP4</i> genes in 361,194 individuals reveals novel insights in the genetics of hereditary and senile systemic amyloidoses

2019-07-08

Abstract excerpt

<h4>ABSTRACT</h4> Transthyretin ( TTR ) gene has a causal role in a hereditary form of amyloidosis (ATTRm) and is potentially involved in the risk of senile systemic amyloidosis (SSA). To understand the genetics of ATTRm and SSA, we conducted a phenome-wide association study of TTR gene in 361,194 participants of European descent testing coding and non-coding variants. Among the 382 clinically-relevant phenotypes...

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Literature Corpus work
2b011be1-2584-5f2f-be37-6d41f0db6f83
DOI
10.1101/19001537
Open publication

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Phenome-wide association study of <i>TTR</i> and <i>RBP4</i> genes in 361,194 individuals reveals novel insights in the genetics of hereditary and senile systemic amyloidosesDOI 10.1101/19001537
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