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SUMO protease FUG1, histone reader AL3 and the PRC1 Complex are integral to repeat-expansion induced epigenetic silencing in <i>Arabidopsis thaliana</i>

2023-01-14

Abstract excerpt

Epigenetic gene silencing induced by expanded repeats can cause diverse phenotypes ranging from severe growth defects in plants to genetic diseases such as Friedreich’s ataxia in humans 1 . The molecular mechanisms underlying repeat expansion-induced epigenetic silencing remain largely unknown 2,3 . Using a plant model, we have previously shown that expanded repeats can induce smallRNAs which in turn can lead to...

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Literature Corpus work
d5a6f9d2-1058-53fe-9a07-f29faf0b6e5e
DOI
10.1101/2023.01.13.523841
Open publication

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