Article

Apolipoprotein L1 Dynamics in Human Parietal Epithelial Cell Molecular Phenotype Kinetics

2018-02-04

Abstract excerpt

Human Parietal Epithelial cells (PECs) are considered as a source of progenitor cells to sustain podocyte (PD) homeostasis. We hypothesized that the absence of apolipoprotein (APO) L1 favors the PEC phenotype and that induction of APOL1 transitions to PD renewal. During PECs’ transition, APOL1 expression coincided with the expression of PD markers (PEC transition) along with down regulation of miR193a. The inducti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d5684b42-836b-50ee-8cc4-916773fae851
DOI: 10.1101/259267

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest

Apolipoprotein L1 Dynamics in Human Parietal Epithelial Cell Molecular Phenotype KineticsDOI 10.1101/259267Read

APOL1-miR-193 Axis as a Bifunctional Regulator of the Glomerular Parietal Epithelium: Maintaining Parietal Cell Phenotype versus Promoting Podocyte Differentiation.Semantic proximity Read

MicroRNA-193a Regulates the Transdifferentiation of Human Parietal Epithelial Cells toward a Podocyte Phenotype.Semantic proximity Read

Disruption of APOL1-miR193a Axis Induces Disorganization of Podocyte Actin CytoskeletonSemantic proximity Read

MiR193a Modulation and Podocyte Phenotype.Semantic proximity Read

Modulation of apolipoprotein L1-microRNA-193a axis prevents podocyte dedifferentiation in high-glucose milieu.Semantic proximity Read

Novel Human Podocyte Cell Model Carrying G2/G2 APOL1 High-Risk Genotype.Semantic proximity Read

Inflammatory proteolysis generates pathogenic APOL1 fragments with distinct intracellular toxicities in podocytes derived from children with HIV associated nephropathy.Semantic proximity Read

De novo expression of podocyte proteins in parietal epithelial cells during experimental glomerular disease.Semantic proximity Read