Article

A Novel ALK Gene Mutation and Its Response to Second-Generation TKIs: a Case Report and Literature Review

2023-06-09

Abstract excerpt

<h4>Background: </h4> Adenocarcinoma with positive echinoderm microtubule-associated protein-like 4 gene and anaplastic lymphoma kinase (EML4-ALK) gene fusion accounts for 3–7% of lung cancer cases and can be targeted with ALK tyrosine kinase inhibitors (TKIs). Second-generation TKIs are the standard of care for targeted populations, especially those with central nervous system (CNS) metastasis. However, most pati...

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Literature Corpus work: d5081138-10f0-5b6b-a483-0766ce7a6a99
DOI: 10.21203/rs.3.rs-2980163/v1

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