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Acquired EML4-ALK fusion and EGFR C797S in cis mutation as resistance mechanisms to osimertinib in a non-small cell lung cancer patient with EGFR L858R/T790M.

Anti-cancer drugs - 1 Nov 2023

Wang Liang-Sheng, Chen Shi-Qi, Zhong Xue, Jiao Xiao-Dong, Liu Ke, Qin Bao-Dong, Wu Ying, Ling Yan, Duan Xiao-Peng, Zang Yuan-Sheng

Abstract excerpt

The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) dramatically improve the clinical outcomes of non-small cell lung cancer (NSCLC) patients harboring EGFR -sensitive mutations. Despite the remarkable efficacy of first-and second-generation EGFR TKIs, disease relapse is inevitable. EGFR T790M mutation is a primary contributor to the acquired resistance to first- and second-generation...

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PMID: 36728908
DOI: 10.1097/CAD.0000000000001489

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